|
In this brief review, I have attempted to consider some aspects of ( the chemistry and physiology of HPRL (human pituitary prolactin). With the availability of specific radioimmunoassay for HPRL, it should be possible to define the role of prolactin in man more clearly. High levels have been found in the sera of pregnant women and infants up to 6 weeks of age, as well as in amniotic fluid. HPRL secretion is predominantly under inhibitory control by the hypothalamus, The release of prolactin- . inhibitory factor is regulated by dopaminergic fibers. Stress, exercise, certain tumors, and drugs (TRH, phenothiazines) increase PRL secretion, while L-dopamine and CB154 lower it. This information is now being applied to several diagnostic and therapeutic problems. PRL stimulation and suppression tests as an index of hypothalamic and pituitary, function have been developed. Attempts to increase milk volume as well as protein and fat content in lactationally deficient mothers by increasing. the HPRL concentration have been carried out. It is concluded that HPRL is essential for the onset and maintenance of milk secretion.
|